{"id":31025,"date":"2018-05-22T09:15:07","date_gmt":"2018-05-22T16:15:07","guid":{"rendered":"https:\/\/womensvoice.com\/en-ca\/?p=31025"},"modified":"2020-06-02T10:41:18","modified_gmt":"2020-06-02T17:41:18","slug":"berberine-metabolic-master-switch","status":"publish","type":"post","link":"https:\/\/womensvoice.com\/en-ca\/articles\/expert-advice\/berberine-metabolic-master-switch\/","title":{"rendered":"Berberine: Nature&#8217;s Metabolic Master Switch"},"content":{"rendered":"<p>[et_pb_section bb_built=&#8221;1&#8243; _builder_version=&#8221;3.0.105&#8243;][et_pb_row _builder_version=&#8221;3.0.47&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221;][et_pb_column type=&#8221;4_4&#8243;][et_pb_image admin_label=&#8221;Image &#8211; Berberine&#8221; src=&#8221;https:\/\/womensvoice.com\/en-ca\/wp-content\/uploads\/sites\/4\/2018\/05\/WVMag_V4_Web-Berberine_header.png&#8221; _builder_version=&#8221;3.0.105&#8243; show_in_lightbox=&#8221;off&#8221; url_new_window=&#8221;off&#8221; use_overlay=&#8221;off&#8221; always_center_on_mobile=&#8221;on&#8221; force_fullwidth=&#8221;off&#8221; show_bottom_space=&#8221;on&#8221; \/][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;3.0.105&#8243; border_width_bottom=&#8221;5px&#8221; border_color_bottom=&#8221;#ffffff&#8221;][et_pb_column type=&#8221;1_3&#8243;][et_pb_text _builder_version=&#8221;3.0.105&#8243; border_color_all=&#8221;#000000&#8243; border_width_bottom=&#8221;5px&#8221;]<\/p>\n<p>\nThe mechanism of action underlying berberine\u2019s in influence on health is due primarily to its action on adenosine monophosphate-activated protein kinase (AMPK).<\/p>\n<blockquote>\n<p><strong>AMPK is an enzyme which acts as a central energy control switch regulating how energy is produced and used in the body.<\/strong><\/p>\n<\/blockquote>\n<p>It is sometimes referred to as the \u201cmetabolic master switch\u201d because it responds to changes in energy metabolism on a cellular and whole-body level. AMPK regulates various biological activities that normalize lipid, glucose, and energy imbalances.<\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;3.0.105&#8243; border_color_all=&#8221;#000000&#8243; background_layout=&#8221;light&#8221;]<\/p>\n<h2>Metabolic Syndrome &amp; <span class=\"berberine-h2-highlight\">Diabetes<\/span><\/h2>\n<blockquote>\n<p>Metabolic syndrome (MetS) is a group of conditions that increase the risk of cardiovascular disease, type 2 diabetes, and premature mortality.<\/p>\n<\/blockquote>\n<p>MetS occurs when these AMPK- regulated pathways are turned on, triggering a syndrome that includes increased blood sugar, inflammation, abdominal obesity, hypertension, lipid abnormalities, and energy imbalances.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243;][et_pb_text _builder_version=&#8221;3.0.105&#8243;]<\/p>\n<p>\nOnly a few chemicals are known to activate AMPK. Berberine is one of them as well as resveratrol and the prescription medication Metformin. Many studies show that berberine can significantly reduce blood sugar levels in individuals with type 2 diabetes. In fact, its effectiveness is comparable to the popular diabetes drug Metformin.<\/p>\n<p>[\/et_pb_text][et_pb_image src=&#8221;https:\/\/womensvoice.com\/en-ca\/wp-content\/uploads\/sites\/4\/2018\/04\/WVMag_V4_Web-Berberine_callout.png&#8221; _builder_version=&#8221;3.0.105&#8243; show_in_lightbox=&#8221;off&#8221; url_new_window=&#8221;off&#8221; use_overlay=&#8221;off&#8221; always_center_on_mobile=&#8221;on&#8221; force_fullwidth=&#8221;off&#8221; show_bottom_space=&#8221;on&#8221; \/][et_pb_text _builder_version=&#8221;3.0.105&#8243;]<\/p>\n<p>\n<strong>Berberine works via multiple different mechanisms:<\/strong><\/p>\n<ul>\n<li>Decreases insulin resistance<\/li>\n<li>Helps the body break down sugars inside cells (glycolysis)<\/li>\n<li>Decreases sugar production in the liver<\/li>\n<li>Slows the breakdown of carbohydrates in the gut<\/li>\n<li>Increases the number of beneficial bacteria in the gut<\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243;][et_pb_text _builder_version=&#8221;3.0.105&#8243; border_color_all=&#8221;#000000&#8243; border_width_bottom=&#8221;5px&#8221; background_layout=&#8221;light&#8221; header_2_font_size=&#8221;32px&#8221; header_2_font=&#8221;Times New Roman||||||||&#8221;]<\/p>\n<h2>Berberine<\/h2>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;3.0.105&#8243; border_color_all=&#8221;#000000&#8243; border_width_bottom=&#8221;5px&#8221;]<\/p>\n<p>\n<strong>Nature&#8217;s best-kept secret for:<\/strong><\/p>\n<ul>\n<li>Weight loss<\/li>\n<li>Blood sugar<\/li>\n<li>Heart health<\/li>\n<\/ul>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;3.0.105&#8243; border_color_all=&#8221;#000000&#8243; border_width_bottom=&#8221;5px&#8221;]<\/p>\n<p>\n<strong>There have been approximately<\/strong> <span class=\"text-callout\">2,800 scientific studies&#8230;<\/span> over one-third of these studies have been published in the last 5 years.<\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;3.0.105&#8243; border_color_all=&#8221;#000000&#8243; border_width_bottom=&#8221;5px&#8221;]<\/p>\n<p>\n<strong>Natural alkaloid<\/strong> found in a wide variety of traditional herbs, including plants such as goldenseal, Oregon grape, and barberry.<\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;3.0.105&#8243; border_color_all=&#8221;#000000&#8243;]<\/p>\n<p>\n<strong>Primarily used<\/strong> for its antimicrobial (bacteria, fungi, protozoa, viruses), anti-inflammatory, and immune-enhancing properties. However, newer research is uncovering<br \/>\nthat berberine\u2019s value extends far beyond these benefits.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;3.0.105&#8243; border_color_all=&#8221;#ffffff&#8221; border_width_top=&#8221;5px&#8221; border_color_top=&#8221;#cccccc&#8221;][et_pb_column type=&#8221;4_4&#8243;][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;3.0.105&#8243; border_width_bottom=&#8221;5px&#8221; border_color_bottom=&#8221;#ffffff&#8221; module_class_1=&#8221;rounded-corners&#8221;][et_pb_column type=&#8221;1_3&#8243;][et_pb_text _builder_version=&#8221;3.0.105&#8243; background_layout=&#8221;light&#8221;]<\/p>\n<p>\n<em>In one study of 116 diabetic patients, taking 1 g of berberine per day lowered fasting blood sugar by 20%, from 7.0 to 5.6 mmol\/L (126 to 101 mg\/dL), or from diabetic to normal levels<br \/>\n<\/em><\/p>\n<p>[\/et_pb_text][et_pb_image _builder_version=&#8221;3.0.105&#8243; src=&#8221;https:\/\/womensvoice.com\/en-ca\/wp-content\/uploads\/sites\/4\/2018\/04\/WVMag_V4_Web-Berberine_graph1.png&#8221; show_in_lightbox=&#8221;off&#8221; url_new_window=&#8221;off&#8221; use_overlay=&#8221;off&#8221; always_center_on_mobile=&#8221;on&#8221; force_fullwidth=&#8221;off&#8221; show_bottom_space=&#8221;on&#8221; border_width_bottom=&#8221;5px&#8221; border_color_all=&#8221;#cccccc&#8221; \/][et_pb_text _builder_version=&#8221;3.0.105&#8243; background_layout=&#8221;light&#8221;]<\/p>\n<p>\n<em>Berberine also lowered hemoglobin A1c by 12% (a marker for long-term blood sugar levels), and also improved blood lipids like cholesterol and triglycerides.<br \/>\n<\/em><\/p>\n<p>[\/et_pb_text][et_pb_image _builder_version=&#8221;3.0.105&#8243; src=&#8221;https:\/\/womensvoice.com\/en-ca\/wp-content\/uploads\/sites\/4\/2018\/04\/WVMag_V4_Web-Berberine_graph2.png&#8221; show_in_lightbox=&#8221;off&#8221; url_new_window=&#8221;off&#8221; use_overlay=&#8221;off&#8221; always_center_on_mobile=&#8221;on&#8221; force_fullwidth=&#8221;off&#8221; show_bottom_space=&#8221;on&#8221; \/][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243;][et_pb_text _builder_version=&#8221;3.0.105&#8243; background_layout=&#8221;light&#8221; border_width_top=&#8221;5px&#8221; custom_padding=&#8221;1em|||&#8221; border_color_all=&#8221;#000000&#8243;]<\/p>\n<h2>Berberine &amp; <span class=\"berberine-h2-highlight\">Weight Loss<\/span><\/h2>\n<p>AMPK activation is reported to underlie berberine\u2019s anti-obesity effects and favourable influence on weight loss by boosting fat burning in the mitochondria. Overall, studies show that berberine is a potent lipid-lowering compound that has a moderate weight loss effect. Berberine also plays a role in enhancing brown fat activity.<\/p>\n<blockquote>\n<p>Brown fat is a heat-generating type of fat that burns energy instead of storing it, and this may have important implications when it comes to weight loss.<\/p>\n<\/blockquote>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;3.19.18&#8243; border_width_top=&#8221;5px&#8221; custom_padding=&#8221;1em|||&#8221; border_color_top=&#8221;#000000&#8243;]<\/p>\n<h2>Berberine &amp; <span class=\"berberine-h2-highlight\">Heart Health<\/span><\/h2>\n<p>Another study showed that berberine reduced total cholesterol low-density lipoprotein (LDL-c) and triglyceride (TG) levels. TG levels play a significant role in the development of coronary heart disease.<\/p>\n<blockquote>\n<p>Berberine has been shown to decrease abnormally high concentrations of fats and lipids by promoting the excretion of cholesterol from the liver, reducing inflammation, and inhibiting the intestinal absorption of cholesterol.<\/p>\n<\/blockquote>\n<p>In addition, part of berberine\u2019s positive e ect on heart health is its ability to help regulate blood sugar levels and reduce obesity to lessen the risk of coronary heart disease.<\/p>\n<p>Many consumers are not familiar with <a href=\"https:\/\/naturalfactors.com\/product\/wellbetx-berberine\/\" target=\"_blank\" rel=\"noopener noreferrer\">berberine as a dietary supplement<\/a>, and it\u2019s not a household word yet, but this little-known all-natural plant- based alkaloid is making headlines and has solid research showing vast health benefits.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243;][et_pb_text _builder_version=&#8221;3.0.105&#8243; background_layout=&#8221;light&#8221; header_2_font_size=&#8221;32px&#8221; header_2_font=&#8221;Times New Roman||||||||&#8221; custom_margin=&#8221;||0em|&#8221; custom_padding=&#8221;||0em|&#8221;]<\/p>\n<h2>References<\/h2>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;3.0.105&#8243; background_layout=&#8221;light&#8221; border_width_top=&#8221;3px&#8221; custom_padding=&#8221;1em|||&#8221; text_font_size=&#8221;12px&#8221; border_color_all=&#8221;#000000&#8243;]<\/p>\n<p>\nDyck J, Lopaschuk GD. AMPK alterations in cardiac physiology and pathology: enemy or ally? J Physiol. 2006 July; 574(1):95-112.<\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;3.0.105&#8243; background_layout=&#8221;light&#8221; border_width_top=&#8221;3px&#8221; custom_padding=&#8221;1em|||&#8221; text_font_size=&#8221;12px&#8221; border_color_all=&#8221;#000000&#8243;]<\/p>\n<p>\nHardie G. AMPK: A target for drugs and natural products with effects on both diabetes and cancer. Diabetes. 2013 Jul; 62(7):2164-2172.<\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;3.0.105&#8243; background_layout=&#8221;light&#8221; border_width_top=&#8221;3px&#8221; custom_padding=&#8221;1em|||&#8221; text_font_size=&#8221;12px&#8221; border_color_all=&#8221;#000000&#8243;]<\/p>\n<p>\nKola B. Role of AMP-activated protein kinase in the control of appetite. J Neuroendocrinol. 2008 Jul; 20(7):942-951.<\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;3.0.105&#8243; background_layout=&#8221;light&#8221; border_width_top=&#8221;3px&#8221; custom_padding=&#8221;1em|||&#8221; text_font_size=&#8221;12px&#8221; border_color_all=&#8221;#000000&#8243;]<\/p>\n<p>\nShirwany NA, Zou MH. AMPK in cardiovascular health and disease. Acta Pharmacol Sin. 2010 Sep; 31(9):1075-1084<\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;3.0.105&#8243; background_layout=&#8221;light&#8221; border_width_top=&#8221;3px&#8221; custom_padding=&#8221;1em|||&#8221; text_font_size=&#8221;12px&#8221; border_color_all=&#8221;#000000&#8243;]<\/p>\n<p>\nWinder WW, Hardie DG. AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes. Am J Physiol. 1999 Jul; 277(1 Pt 1):E1-10.<\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;3.0.105&#8243; background_layout=&#8221;light&#8221; border_width_top=&#8221;3px&#8221; custom_padding=&#8221;1em|||&#8221; text_font_size=&#8221;12px&#8221; border_color_all=&#8221;#000000&#8243;]<\/p>\n<p>\nXu JH, Liu XZ, Wei Pan W, et al. Berberine protects against diet-induced obesity through regulating metabolic endotoxemia and gut hormone levels. Mol Med Rep. 2017 May; 15(5):2765-2787.<\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;3.0.105&#8243; background_layout=&#8221;light&#8221; border_width_top=&#8221;3px&#8221; custom_padding=&#8221;1em|||&#8221; text_font_size=&#8221;12px&#8221; border_color_all=&#8221;#000000&#8243;]<\/p>\n<p>\nXu JH, Liu XZ, Wei Pan W, et al. Berberine protects against diet-induced obesity through regulating metabolic endotoxemia and gut hormone levels. Mol Med Rep. 2017 May; 15(5):2765-2787.<\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;3.19.18&#8243; background_layout=&#8221;light&#8221; border_width_top=&#8221;3px&#8221; custom_padding=&#8221;1em|||&#8221; text_font_size=&#8221;12px&#8221; border_color_all=&#8221;#000000&#8243;]<\/p>\n<p>\nYin J, Xing H, Ye J. Ef cacy of berberine in patients with type 2 diabetes. Metabolism. 2008 May; 57(5):712-717.<\/p>\n<p>[\/et_pb_text][et_pb_image _builder_version=&#8221;3.19.18&#8243; src=&#8221;https:\/\/womensvoice.com\/en-ca\/wp-content\/uploads\/sites\/4\/2018\/04\/WVMag_V4_Web-Berberine_product.jpg&#8221; url_new_window=&#8221;on&#8221; url=&#8221;https:\/\/naturalfactors.com\/product\/wellbetx-berberine\/&#8221; \/][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n<span class=\"et_bloom_bottom_trigger\"><\/span>","protected":false},"excerpt":{"rendered":"<p>The mechanism of action underlying berberine\u2019s in influence on health is due primarily to its action on adenosine monophosphate-activated protein kinase (AMPK). AMPK is an enzyme which acts as a central energy control switch regulating how energy is produced and used in the body. It is sometimes referred to as the \u201cmetabolic master switch\u201d because [&hellip;]<\/p>\n","protected":false},"author":9,"featured_media":32952,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","apple_news_api_created_at":"","apple_news_api_id":"","apple_news_api_modified_at":"","apple_news_api_revision":"","apple_news_api_share_url":"","apple_news_cover_media_provider":"image","apple_news_coverimage":0,"apple_news_coverimage_caption":"","apple_news_cover_video_id":0,"apple_news_cover_video_url":"","apple_news_cover_embedwebvideo_url":"","apple_news_is_hidden":"","apple_news_is_paid":"","apple_news_is_preview":"","apple_news_is_sponsored":"","apple_news_maturity_rating":"","apple_news_metadata":"\"\"","apple_news_pullquote":"","apple_news_pullquote_position":"","apple_news_slug":"","apple_news_sections":[],"apple_news_suppress_video_url":false,"apple_news_use_image_component":false,"footnotes":""},"categories":[14,1,13],"tags":[3797,3783,3790,3795],"class_list":["post-31025","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-expert-advice","category-health","category-nutrition","tag-blood-sugar","tag-healthy-weight","tag-heart-health","tag-nutrition","et-has-post-format-content","et_post_format-et-post-format-standard"],"apple_news_notices":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Berberine: Nature&#039;s Metabolic Master Switch - Women&#039;s Voice (CA)<\/title>\n<meta name=\"description\" content=\"Many studies show that berberine (nature&#039;s master switch) can significantly reduce blood sugar levels in individuals with type 2 diabetes.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/womensvoice.com\/en-ca\/articles\/expert-advice\/berberine-metabolic-master-switch\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Berberine: Nature&#039;s Metabolic Master Switch\" \/>\n<meta property=\"og:description\" content=\"Many studies show that berberine (nature&#039;s master switch) can significantly reduce blood sugar levels in individuals with type 2 diabetes.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/womensvoice.com\/en-ca\/articles\/expert-advice\/berberine-metabolic-master-switch\/\" \/>\n<meta property=\"og:site_name\" content=\"Women&#039;s Voice (CA)\" \/>\n<meta property=\"article:published_time\" content=\"2018-05-22T16:15:07+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-06-02T17:41:18+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/womensvoice.com\/en-ca\/wp-content\/uploads\/sites\/4\/2018\/05\/Berberine-Natures-Metabolic-Master-Switch.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"596\" \/>\n\t<meta property=\"og:image:height\" content=\"449\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Karen Jensen, ND\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Karen Jensen, ND\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/womensvoice.com\\\/en-ca\\\/articles\\\/expert-advice\\\/berberine-metabolic-master-switch\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/womensvoice.com\\\/en-ca\\\/articles\\\/expert-advice\\\/berberine-metabolic-master-switch\\\/\"},\"author\":{\"name\":\"Karen Jensen, ND\",\"@id\":\"https:\\\/\\\/womensvoice.com\\\/en-ca\\\/#\\\/schema\\\/person\\\/611de52ea4ab588142ae66a146c064f1\"},\"headline\":\"Berberine: Nature&#8217;s Metabolic Master Switch\",\"datePublished\":\"2018-05-22T16:15:07+00:00\",\"dateModified\":\"2020-06-02T17:41:18+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/womensvoice.com\\\/en-ca\\\/articles\\\/expert-advice\\\/berberine-metabolic-master-switch\\\/\"},\"wordCount\":1496,\"image\":{\"@id\":\"https:\\\/\\\/womensvoice.com\\\/en-ca\\\/articles\\\/expert-advice\\\/berberine-metabolic-master-switch\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/womensvoice.com\\\/en-ca\\\/wp-content\\\/uploads\\\/sites\\\/4\\\/2018\\\/05\\\/Berberine-Natures-Metabolic-Master-Switch.jpg\",\"keywords\":[\"Blood Sugar\",\"Healthy Weight\",\"Heart Health\",\"Nutrition\"],\"articleSection\":[\"Expert Advice\",\"Health &amp; 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