{"id":43005,"date":"2024-06-19T12:32:33","date_gmt":"2024-06-19T19:32:33","guid":{"rendered":"https:\/\/womensvoice.com\/en-ca\/?p=43005"},"modified":"2024-07-02T13:26:22","modified_gmt":"2024-07-02T20:26:22","slug":"maximize-berberines-bioavailability","status":"publish","type":"post","link":"https:\/\/womensvoice.com\/en-ca\/articles\/health\/maximize-berberines-bioavailability\/","title":{"rendered":"Maximize Berberine’s Bioavailability"},"content":{"rendered":"

[et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”4.16″ collapsed=”off” global_colors_info=”{}”][et_pb_fullwidth_image src=”https:\/\/womensvoice.com\/en-ca\/wp-content\/uploads\/sites\/4\/2024\/06\/berberine_banner.png” alt=”Title: The Soil Crisis.
\nImage of a bare foot on brown soil” title_text=”berberine_banner” admin_label=”Fullwidth Image” _builder_version=”4.25.2″ vertical_offset_tablet=”0″ horizontal_offset_tablet=”0″ z_index_tablet=”500″ box_shadow_horizontal_tablet=”0px” box_shadow_vertical_tablet=”0px” box_shadow_blur_tablet=”40px” box_shadow_spread_tablet=”0px” global_colors_info=”{}”][\/et_pb_fullwidth_image][et_pb_fullwidth_code raw_content_tablet=”<\/p>\n

Parents face ongoing challenges in raising healthy, well-nourished children in a world where sugary temptations lurk around every corner.<\/p>\n

” raw_content_phone=”” raw_content_last_edited=”on|desktop” admin_label=”Text – Fullwidth Leader Text” module_id=”fullwidth-leader-text” _builder_version=”4.25.2″ vertical_offset_tablet=”0″ horizontal_offset_tablet=”0″ z_index_tablet=”500″ box_shadow_horizontal_tablet=”0px” box_shadow_vertical_tablet=”0px” box_shadow_blur_tablet=”40px” box_shadow_spread_tablet=”0px” global_colors_info=”{}”]In natural health remedies, berberine stands out as a potent plant compound that offers multiple health benefits.<\/pee>[\/et_pb_fullwidth_code][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ collapsed=”off” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text admin_label=”Text – Body Content” _builder_version=”4.25.2″ header_font=”|700|||||||” header_text_color=”#509aa6″ header_font_size=”40px” header_line_height=”40px” vertical_offset_tablet=”0″ horizontal_offset_tablet=”0″ hover_enabled=”0″ header_font_size_tablet=”” header_font_size_phone=”30px” header_font_size_last_edited=”on|phone” header_letter_spacing_last_edited=”off|phone” header_line_height_tablet=”” header_line_height_phone=”30px” header_line_height_last_edited=”on|phone” z_index_tablet=”500″ text_text_shadow_horizontal_length_tablet=”0px” text_text_shadow_vertical_length_tablet=”0px” text_text_shadow_blur_strength_tablet=”1px” link_text_shadow_horizontal_length_tablet=”0px” link_text_shadow_vertical_length_tablet=”0px” link_text_shadow_blur_strength_tablet=”1px” ul_text_shadow_horizontal_length_tablet=”0px” ul_text_shadow_vertical_length_tablet=”0px” ul_text_shadow_blur_strength_tablet=”1px” ol_text_shadow_horizontal_length_tablet=”0px” ol_text_shadow_vertical_length_tablet=”0px” ol_text_shadow_blur_strength_tablet=”1px” quote_text_shadow_horizontal_length_tablet=”0px” quote_text_shadow_vertical_length_tablet=”0px” quote_text_shadow_blur_strength_tablet=”1px” header_text_shadow_horizontal_length_tablet=”0px” header_text_shadow_vertical_length_tablet=”0px” header_text_shadow_blur_strength_tablet=”1px” header_2_text_shadow_horizontal_length_tablet=”0px” header_2_text_shadow_vertical_length_tablet=”0px” header_2_text_shadow_blur_strength_tablet=”1px” header_3_text_shadow_horizontal_length_tablet=”0px” header_3_text_shadow_vertical_length_tablet=”0px” header_3_text_shadow_blur_strength_tablet=”1px” header_4_text_shadow_horizontal_length_tablet=”0px” header_4_text_shadow_vertical_length_tablet=”0px” header_4_text_shadow_blur_strength_tablet=”1px” header_5_text_shadow_horizontal_length_tablet=”0px” header_5_text_shadow_vertical_length_tablet=”0px” header_5_text_shadow_blur_strength_tablet=”1px” header_6_text_shadow_horizontal_length_tablet=”0px” header_6_text_shadow_vertical_length_tablet=”0px” header_6_text_shadow_blur_strength_tablet=”1px” box_shadow_horizontal_tablet=”0px” box_shadow_vertical_tablet=”0px” box_shadow_blur_tablet=”40px” box_shadow_spread_tablet=”0px” global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

In natural health remedies, berberine stands out as a potent plant compound that offers multiple health benefits. However, studies report berberine\u2019s low bioavailability<\/strong> and poor absorption in the body (at less than 5%) after oral intake.<\/p>\n

WHAT IS BIOAVAILABILITY<\/em>, AND WHY<\/em> DOES IT MATTER?<\/span><\/strong><\/h5>\n

Have you ever taken a supplement and wondered if it worked for you? The answer lies in a principle known as \u201cbioavailability.\u201d Bioavailability determines how well your body absorbs a compound, like a drug or nutrient.<\/p>\n

\u2022 High bioavailability<\/strong> means more substance is absorbed into the bloodstream, increasing its therapeutic effectiveness, and ensuring you get the most out of a treatment.\u00a0<\/span><\/p>\n

\u2022 Low bioavailability<\/strong> means that higher doses are required for health benefits, which can increase treatment costs and the chance of side effects (i.e., gastrointestinal side effects).\u00a0 <\/span>\u00a0<\/span><\/p>\n

Just like so many other natural\/herbal compounds, berberine faces absorption challenges in the body because of its poor water solubility and rapid metabolism by the gut and liver. Generally, a compound absorbs best when it has both water and fat solubility so it can pass through the gastrointestinal environment and penetrate the cell membranes to ultimately reach the bloodstream. Furthermore, smaller compounds are generally better absorbed by our cells than larger ones.\u00a0 \u00a0<\/span><\/p>\n

BERBERINE’S BIOAVAILABILITY<\/strong><\/h5>\n

Scientists are exploring different formulations (so-called \u201cdelivery systems\u201d) to enhance berberine\u2019s absorption, making it more available for the body and potentially improving its therapeutic effects. To date, only a few human clinical studies have been conducted on advanced delivery systems of berberine.<\/p>\n

As a group of leading scientists in a new clinical study, my colleagues and I found that LipoMicel<\/strong>\u00ae<\/sup>,<\/b> a new delivery system of berberine, has up to six times better absorption in human participants than standard berberine. In a second study, LipoMicel could achieve blood glucose reductions of 12% in participants in as little as two days \u2013 after only two doses of 500 mg\/day. For comparison, in most clinical studies, standard berberine treatment, administered at a higher dose of 900\u20132000 mg\/day, would take at least two weeks<\/i> to reduce blood glucose in type 2 diabetes patients.<\/p>\n

HOW DOES LIPOMICEL WORK?<\/strong><\/h5>\n

LipoMicel disperses berberine into microparticles, mixing it with both water-soluble and fat-soluble ingredients to create a natural emulsion (i.e., an oil-in-water mixture, like a vinaigrette!). These tiny particles, called micelles,<\/strong> have a unique structure with a core like oils (lipophilic) and an outer part like water (hydrophilic). \u00a0<\/span><\/p>\n

By encapsulating and solubilizing berberine in LipoMicel, berberine can safely travel through the digestive system \u2013 protected from degradation by enzymes and gut bacteria \u2013 to reach the bloodstream and, ultimately, the tissue\u2019s therapeutic target(s).\u00a0 \u00a0<\/span><\/p>\n

BENEFITS OF A HIGH BIOAVAILABLE FORMULATION<\/span><\/strong><\/h5>\n

Formulations with higher bioavailability can provide faster and greater<\/strong> health benefits than standard formulations. More importantly, because of the higher absorption, lower doses of berberine can be used, which reduces the risk of common gastrointestinal side effects such as constipation or an upset stomach.\u00a0<\/span><\/p>\n

RISKS, SIDE EFFECTS, AND INTERACTIONS WITH BERBERINE LIPOMICEL<\/strong><\/h5>\n

In a 30-day study, LipoMicel treatment proved safe \u2013no significant changes in blood markers such as liver and kidney functions were observed, and study participants reported no side effects.<\/p>\n

As berberine can interact with many drugs, which can potentially cause serious side effects, it should not be taken at the same time as other medications. It should also not be used during pregnancy as there\u2019s not enough clinical evidence on berberine\u2019s use in pregnant women.<\/p>\n

THE BEST TIME TO TAKE BERBERINE<\/strong><\/h5>\n

It\u2019s best to take berberine together with a meal, or shortly after, to take advantage of the blood glucose and lipid spikes associated with eating. For example, take it after a heavy\/sugary late-night dinner to prevent a spike in blood sugar levels, which can interfere with the body\u2019s natural sleep-wake cycle.\u00a0<\/span><\/p>\n

ARE ALL BERBERINE SUPPLEMENTS CREATED EQUAL?<\/span>\u00a0 \u00a0<\/span><\/strong><\/h5>\n

Unlike other formulations, LipoMicel technology has been clinically studied in numerous human trials, showing better absorption and clinical efficacy, with results published in peer-reviewed journals. \u00a0<\/span><\/p>\n

If you want the maximum health benefits, choose a product tested in human clinical trials like LipoMicel, ensuring efficacy and safety. Remember, always choose supplements that prioritize quality \u2013 look for the ISURA\u00ae<\/sup> seal, a third-party testing certification.<\/p>\n

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In natural health remedies, berberine stands out as a potent plant compound that offers multiple health benefits. However, studies report berberine\u2019s low bioavailability and poor absorption in the body (at less than 5%) after oral intake. WHAT IS BIOAVAILABILITY, AND WHY DOES IT MATTER? Have you ever taken a supplement and wondered if it worked […]<\/p>\n","protected":false},"author":82,"featured_media":43008,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"

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This is the Full-Width Leader Text that many articles feature. The color changed in the Custom CSS settings in the post editor.<\/p>

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How to Clone this Content (Note: This is an H2)<\/h2>

To make the process of adding new articles to the WV site as simple as possible, please follow these steps.<\/p>

  1. Duplicate the Template Page<\/strong>
    1. In the EN-CA Admin Backend, navigate to Posts<\/li>
    2. Hover over the \"Article Template for Cloning\" post and click \"Duplicate This\"<\/li>
    3. Use the \"Quick Edit\" feature to quickly change the Title, Slug, Author, Category and Tags<\/li>
    4. Use the \"Edit\" link to open the post editor<\/li><\/ol><\/li>
    5. Configure the Header and Feature Images<\/strong>
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          1. Add those to the \"Text - References\" module. This module is set by default to use the proper font sizing and layout.<\/li>
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          3. Add Custom Images<\/strong>
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            4. Update the Yoast SEO Settings<\/strong>
              1. Set the focus keyphrase<\/li>
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              4. Set related posts - preferably based on related phrases\/topics from this article<\/li><\/ol><\/li>
              5. Quick QA Checklist<\/strong>
                1. Preview the layout on mobile to make sure it reads well<\/li>
                2. Make sure all images have ALT Tags<\/li>
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                4. Make sure the article is set to display in a category<\/li>
                5. Make sure the article has tags (if appropriate)<\/li>
                6. Make sure the author is set. If there is no personality author (such as a doctor) set the author to be \"Women's Voice\".<\/li><\/ol><\/li><\/ol>

                  This is an H3 I'm making this long so I can test the line height settings<\/h3>

                  And this is yet another paragraph. Lorem ipsum dolor sit amet, minim molestie argumentum est at, pri legere torquatos instructior ex. Vis id odio atomorum oportere, quem modo fabellas sit at, dicat semper est ne. Apeirian detraxit pri eu. No solum accusam has. Ius ne harum mundi clita, eu pro tation audiam.<\/p>

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                      Sed dicit necessitatibus in, id posse nominati eos. Ea vel dictas facilisi adipiscing, verear phaedrum sed ei, omnes oblique sanctus mea ex. Iudico pertinacia constituam cu eos. Te vel fugit libris, libris nemore no pri, graece oportere sea ea. Amet omnium epicuri cum te, sonet dignissim abhorreant pro ea, mei petentium constituam ad. Suscipit gloriatur necessitatibus has et.<\/p>

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                      References<\/h4>
                      1. Shifren JL, Mons BU, Russo PA, et al. Problems and distress in United States women: prevalence and correlates. Obstet Gynecol. 2008; 112(5):970-978.<\/li>
                      2. Rosenbaum TY. Musculoskeletal pain and sexual function in women. J Med. 2010; 7(2pt 1):645-653.<\/li>
                      3. Davis SR, Van der Mooren MJ, Van Lunsen RH, et al. Efficacy and safety of a testosterone patch for the treatment of hypoactive desire disorder in surgically menopausal women: a randomized placebo-controlled trial. Menopause. 2006; 13(3):387-396.<\/li><\/ol>

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