{"id":43281,"date":"2024-10-16T09:45:02","date_gmt":"2024-10-16T16:45:02","guid":{"rendered":"https:\/\/womensvoice.com\/en-ca\/?p=43281"},"modified":"2024-10-23T10:14:01","modified_gmt":"2024-10-23T17:14:01","slug":"statin-drugs-and-the-lipid-hypothesis","status":"publish","type":"post","link":"https:\/\/womensvoice.com\/en-ca\/articles\/health\/statin-drugs-and-the-lipid-hypothesis\/","title":{"rendered":"Statin Drugs and the Lipid Hypothesis"},"content":{"rendered":"

[et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”4.16″ collapsed=”off” global_colors_info=”{}”][et_pb_fullwidth_image src=”https:\/\/womensvoice.com\/en-ca\/wp-content\/uploads\/sites\/4\/2024\/10\/statin_lipid__banner_1000x480.png” alt=”Middle age woman smiling lifting weights” title_text=”statin_lipid__banner_1000x480″ admin_label=”Fullwidth Image” _builder_version=”4.27.2″ vertical_offset_tablet=”0″ horizontal_offset_tablet=”0″ z_index_tablet=”500″ box_shadow_horizontal_tablet=”0px” box_shadow_vertical_tablet=”0px” box_shadow_blur_tablet=”40px” box_shadow_spread_tablet=”0px” global_colors_info=”{}”][\/et_pb_fullwidth_image][et_pb_fullwidth_code raw_content_tablet=”<\/p>\n

Parents face ongoing challenges in raising healthy, well-nourished children in a world where sugary temptations lurk around every corner.<\/p>\n

” raw_content_phone=”” raw_content_last_edited=”on|desktop” admin_label=”Text – Fullwidth Leader Text” module_id=”fullwidth-leader-text” _builder_version=”4.27.2″ vertical_offset_tablet=”0″ horizontal_offset_tablet=”0″ z_index_tablet=”500″ box_shadow_horizontal_tablet=”0px” box_shadow_vertical_tablet=”0px” box_shadow_blur_tablet=”40px” box_shadow_spread_tablet=”0px” global_colors_info=”{}”]The results based on ARR suggest the benefits of statins are modest.<\/pee>[\/et_pb_fullwidth_code][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ collapsed=”off” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text admin_label=”Text – Body Content” _builder_version=”4.27.2″ header_font=”|700|||||||” header_text_color=”#509aa6″ header_font_size=”40px” header_line_height=”40px” vertical_offset_tablet=”0″ horizontal_offset_tablet=”0″ header_font_size_tablet=”” header_font_size_phone=”30px” header_font_size_last_edited=”on|phone” header_letter_spacing_last_edited=”off|phone” header_line_height_tablet=”” header_line_height_phone=”30px” header_line_height_last_edited=”on|phone” z_index_tablet=”500″ text_text_shadow_horizontal_length_tablet=”0px” text_text_shadow_vertical_length_tablet=”0px” text_text_shadow_blur_strength_tablet=”1px” link_text_shadow_horizontal_length_tablet=”0px” link_text_shadow_vertical_length_tablet=”0px” link_text_shadow_blur_strength_tablet=”1px” ul_text_shadow_horizontal_length_tablet=”0px” ul_text_shadow_vertical_length_tablet=”0px” ul_text_shadow_blur_strength_tablet=”1px” ol_text_shadow_horizontal_length_tablet=”0px” ol_text_shadow_vertical_length_tablet=”0px” ol_text_shadow_blur_strength_tablet=”1px” quote_text_shadow_horizontal_length_tablet=”0px” quote_text_shadow_vertical_length_tablet=”0px” quote_text_shadow_blur_strength_tablet=”1px” header_text_shadow_horizontal_length_tablet=”0px” header_text_shadow_vertical_length_tablet=”0px” header_text_shadow_blur_strength_tablet=”1px” header_2_text_shadow_horizontal_length_tablet=”0px” header_2_text_shadow_vertical_length_tablet=”0px” header_2_text_shadow_blur_strength_tablet=”1px” header_3_text_shadow_horizontal_length_tablet=”0px” header_3_text_shadow_vertical_length_tablet=”0px” header_3_text_shadow_blur_strength_tablet=”1px” header_4_text_shadow_horizontal_length_tablet=”0px” header_4_text_shadow_vertical_length_tablet=”0px” header_4_text_shadow_blur_strength_tablet=”1px” header_5_text_shadow_horizontal_length_tablet=”0px” header_5_text_shadow_vertical_length_tablet=”0px” header_5_text_shadow_blur_strength_tablet=”1px” header_6_text_shadow_horizontal_length_tablet=”0px” header_6_text_shadow_vertical_length_tablet=”0px” header_6_text_shadow_blur_strength_tablet=”1px” box_shadow_horizontal_tablet=”0px” box_shadow_vertical_tablet=”0px” box_shadow_blur_tablet=”40px” box_shadow_spread_tablet=”0px” global_colors_info=”{}”]<\/p>\n

The \u201cLipid Hypothesis,\u201d which suggests that LDL cholesterol is causally related to coronary heart disease (CHD), started gaining attention from the scientific community around 1951. It remained controversial for many years because of the lack of clear evidence. No individual study was compelling enough. In 1984, the NIH Consensus Conference still concluded that lowering LDL with statins could benefit CHD. Statins are prescription medications used to lower cholesterol levels. They function by reducing the amount of cholesterol produced by the liver and aiding the liver in removing cholesterol already in the blood.<\/b><\/h6>\n
STATISTICAL DECEPTION CREATES THE ILLUSION<\/h5>\n

Most studies supporting statin use are based on a statistical tool called relative risk reduction (RRR) to amplify the benefits and minimize risks. For example, if a heart attack occurs in 2% of patients in the placebo group and 1% in the drug-treated group, the RRR value would indicate a 50% reduction of the risk: 1 is 50% of 2.<\/p>\n

Based on absolute risk reduction (ARR), the benefit to the treated population is one percentage point. This result is unlikely to generate enthusiasm from the stakeholders and the public. Most trials routinely report findings for the treatment benefits using RRR without the corresponding ARR benefits and risks.\u00a0<\/span><\/p>\n

A meta-analysis of 21 randomized trials published in JAMA<\/i> examined the efficacy of statins in reducing total mortality and cardiovascular outcomes. The reduction based on ARR was 0.8% for all-cause mortality, 1.3% for myocardial infarction, and 0.4% for stroke, with RRR of 9%, 29%, and 14%, respectively. The results based on ARR suggest the benefits of statins are modest. This information should be communicated to patients in informed clinical decision-making and while deciding clinical guidelines and policies. Currently, one in four people over 45 years in the U.S., and one in ten in Canada, takes statins.<\/p>\n

STATINS MAY MAKE YOUR HEART HEALTH WORSE<\/h5>\n

A report published in the Expert Review of Clinical Pharmacology<\/i> found that statins may cause coronary artery calcification and impair muscle function in the heart and blood vessels through the depletion of CoQ10 and inhibit the synthesis of vitamin K2, a cofactor that protects arteries from calcification. Statins also inhibit selenium proteins, causing deficiency, a factor in congestive heart failure. The review suggested that the use of statin drugs could exacerbate the global epidemic of heart failure and atherosclerosis.\u00a0<\/span><\/p>\n

Health Canada warnings related to statins include rhabdomyolysis (muscle damage), myopathy (muscle pain), memory loss, interstitial lung disease, increased blood sugar, and diabetes. In the U.S., the Food and Drug Administration (FDA) warns about memory loss, confusion, increased blood sugar, and the risk of diabetes. The NIH warns that some statins cause rhabdomyolysis. Rhabdomyolysis can lead to permanent kidney damage, coma, and sometimes death, causing some statin drugs to be taken off the market.<\/p>\n

Statin drugs do reduce cholesterol. They work by blocking the enzyme in your liver responsible for making cholesterol and, yes, your body makes cholesterol because it is essential for survival.\u00a0<\/span><\/p>\n

WHAT DOES CHOLESTEROL DO IN THE BODY AND BRAIN?<\/h5>\n

Cholesterol helps produce cell membranes and plays a role in hormone production, including testosterone, progesterone, estrogen, and bile acids for fat digestion. It is essential for the brain, which contains 25% of the body\u2019s total cholesterol, and it is critical for brain cell connections that allow you to think, learn, and form memories. When cholesterol is reduced, these connections do not work well.<\/p>\n

Supplement support to protect yourself if you are taking statin drugs<\/h5>\n

Coenzyme Q10 (CoQ10)<\/strong> Mitochondria are known as the powerhouse of the cell. They take energy from food and release it as adenosine triphosphate (ATP), which is necessary for muscle contraction, nerve impulses, and protein synthesis. Insufficient CoQ10 inhibits ATP production, and studies suggest that years of statin therapy could result in mitochondrial DNA damage, impairing muscle function in the heart and blood vessels.<\/p>\n

Vitamin K1 <\/strong>is the principal source of dietary vitamin K and is needed for proper blood coagulation. Vitamin K2 is essential for avoiding calcium deposits in the arteries, preventing atherosclerosis-related cardiovascular disease, and building and maintaining strong bones. Vitamin K2 is a crucial cardiovascular health supplement.\u00a0<\/span><\/p>\n

Selenium<\/strong> \u2013 <\/b>Statins can cause selenium deficiency, which has been implicated in developing myopathies. Heart failure induced by selenium deficiency, known as Keshan\u2019s disease, a highly lethal cardiomyopathy, was first identified in the 1930s.<\/p>\n

Vitamin D3 <\/strong>deficiency has been associated with hypertension, atherosclerosis, and heart failure. It plays a crucial role in cholesterol plaque vulnerability, and vitamin D3 deficiency associated with statin drug administration can accelerate atherosclerosis (which affects the brain).<\/p>\n

Your health and well-being should be your top priority when taking any medication. Fortunately, numerous dietary supplements can significantly support your body and aid in reducing any side effects that may occur from medication (statin) use. Combining the right supplements with a healthy lifestyle can ensure better support for your body and overall health.<\/p>\n

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The \u201cLipid Hypothesis,\u201d which suggests that LDL cholesterol is causally related to coronary heart disease (CHD), started gaining attention from the scientific community around 1951. It remained controversial for many years because of the lack of clear evidence. No individual study was compelling enough. In 1984, the NIH Consensus Conference still concluded that lowering LDL […]<\/p>\n","protected":false},"author":9,"featured_media":43283,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"

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This is the Full-Width Leader Text that many articles feature. The color changed in the Custom CSS settings in the post editor.<\/p>

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How to Clone this Content (Note: This is an H2)<\/h2>

To make the process of adding new articles to the WV site as simple as possible, please follow these steps.<\/p>

  1. Duplicate the Template Page<\/strong>
    1. In the EN-CA Admin Backend, navigate to Posts<\/li>
    2. Hover over the \"Article Template for Cloning\" post and click \"Duplicate This\"<\/li>
    3. Use the \"Quick Edit\" feature to quickly change the Title, Slug, Author, Category and Tags<\/li>
    4. Use the \"Edit\" link to open the post editor<\/li><\/ol><\/li>
    5. Configure the Header and Feature Images<\/strong>
      1. Change the full-width header image<\/li>
      2. Navigate to the \"Advanced\" tab of the image module and set the ALT TAG for the image<\/li>
      3. Remove the placeholder feature image<\/li>
      4. Change the feature header image, be sure to set the ALT TAG before setting the feature image<\/li><\/ol><\/li>
      5. Add the Written Content<\/strong>
        1. Copy the text from the PDF article into a PLAIN TEXT editor<\/li>
        2. Clean up the text, remove any extra spaces<\/li>
        3. Copy and paste the text from the PLAIN TEXT editor into the \"Text - Body Content\" module<\/li>
        4. Keep the text modification as simple as possible. Use H2-H6 titles, use blockquotes, etc<\/li>
        5. Modify the CSS in the Custom CSS section of the page (rather than changing the Divi content). Keep it simple by only marginally changing the font sizes and colours.<\/li>
        6. Add the EXCERPT to the post settings<\/li>
        7. Add TITLE tags for any links in the article<\/li>
        8. If there are references in the article
          1. Add those to the \"Text - References\" module. This module is set by default to use the proper font sizing and layout.<\/li>
          2. Add links to the references using the #references bookmark ID<\/li><\/ol><\/li><\/ol><\/li>
          3. Add Custom Images<\/strong>
            1. As simply as possible, add images from the PDF article into the HTML text<\/li>
            2. Don't get carried away with adding every image in-line as it appears in the magazine<\/li>
            3. Once an image is set, make sure you have an ALT TAG set for it<\/li><\/ol><\/li>
            4. Update the Yoast SEO Settings<\/strong>
              1. Set the focus keyphrase<\/li>
              2. Set the meta description<\/li>
              3. Set the related keyphrases (if appropriate)<\/li>
              4. Set related posts - preferably based on related phrases\/topics from this article<\/li><\/ol><\/li>
              5. Quick QA Checklist<\/strong>
                1. Preview the layout on mobile to make sure it reads well<\/li>
                2. Make sure all images have ALT Tags<\/li>
                3. Make sure all links have TITLE tags<\/li>
                4. Make sure the article is set to display in a category<\/li>
                5. Make sure the article has tags (if appropriate)<\/li>
                6. Make sure the author is set. If there is no personality author (such as a doctor) set the author to be \"Women's Voice\".<\/li><\/ol><\/li><\/ol>

                  This is an H3 I'm making this long so I can test the line height settings<\/h3>

                  And this is yet another paragraph. Lorem ipsum dolor sit amet, minim molestie argumentum est at, pri legere torquatos instructior ex. Vis id odio atomorum oportere, quem modo fabellas sit at, dicat semper est ne. Apeirian detraxit pri eu. No solum accusam has. Ius ne harum mundi clita, eu pro tation audiam.<\/p>

                  This is a blockquote. It is meant to stand out and be inspiring for the reader, pulling them through the content.<\/p><\/blockquote>

                  Sed dicit necessitatibus in, id posse nominati eos. Ea vel dictas facilisi adipiscing, verear phaedrum sed ei, omnes oblique sanctus mea ex. Iudico pertinacia constituam cu eos. Te vel fugit libris, libris nemore no pri, graece oportere sea ea. Amet omnium epicuri cum te, sonet dignissim abhorreant pro ea, mei petentium constituam ad. Suscipit gloriatur necessitatibus has et.<\/p>

                  This sentence is an H4 I'm making this long so I can test the line height settings<\/h4>

                  Here is another paragraph. Lorem ipsum dolor sit amet, minim molestie argumentum est at, pri legere torquatos instructior ex. Vis id odio atomorum oportere, quem modo fabellas sit at, dicat semper est ne. Apeirian detraxit pri eu. No solum accusam has. Ius ne harum mundi clita, eu pro tation audiam.<\/p>

                  • This is a bulleted list<\/li>
                  • With a few points to it<\/li>
                  • Good for explaining things in blocks<\/li><\/ul>

                    Lorem ipsum dolor sit amet, minim molestie argumentum est at, pri legere torquatos instructior ex. Vis id odio atomorum oportere, quem modo fabellas sit at, dicat semper est ne. Apeirian detraxit pri eu. No solum accusam has. Ius ne harum mundi clita, eu pro tation audiam.<\/p>

                    This is an example of an H5 I'm making this long so I can test the line height settings<\/h5>

                    Sed dicit necessitatibus in, id posse nominati eos. Ea vel dictas facilisi adipiscing, verear phaedrum sed ei, omnes oblique sanctus mea ex. Iudico pertinacia constituam cu eos. Te vel fugit libris, libris nemore no pri, graece oportere sea ea. Amet omnium epicuri cum te, sonet dignissim abhorreant pro ea, mei petentium constituam ad. Suscipit gloriatur necessitatibus has et.<\/p>

                    1. This is an ordered list<\/li>
                    2. Where items appear with numbers<\/li>
                    3. This is good for explaining a process or ranking<\/li><\/ol>
                      And lastly an H6 I'm making this long so I can test the line height settings<\/h6>

                      Lorem ipsum dolor sit amet, minim molestie argumentum est at, pri legere torquatos instructior ex. Vis id odio atomorum oportere, quem modo fabellas sit at, dicat semper est ne. Apeirian detraxit pri eu. No solum accusam has. Ius ne harum mundi clita, eu pro tation audiam.<\/p>

                      Sed dicit necessitatibus in, id posse nominati eos. Ea vel dictas facilisi adipiscing, verear phaedrum sed ei, omnes oblique sanctus mea ex. Iudico pertinacia constituam cu eos. Te vel fugit libris, libris nemore no pri, graece oportere sea ea. Amet omnium epicuri cum te, sonet dignissim abhorreant pro ea, mei petentium constituam ad. Suscipit gloriatur necessitatibus has et.<\/p>

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                      References<\/h4>
                      1. Shifren JL, Mons BU, Russo PA, et al. Problems and distress in United States women: prevalence and correlates. Obstet Gynecol. 2008; 112(5):970-978.<\/li>
                      2. Rosenbaum TY. Musculoskeletal pain and sexual function in women. J Med. 2010; 7(2pt 1):645-653.<\/li>
                      3. Davis SR, Van der Mooren MJ, Van Lunsen RH, et al. Efficacy and safety of a testosterone patch for the treatment of hypoactive desire disorder in surgically menopausal women: a randomized placebo-controlled trial. Menopause. 2006; 13(3):387-396.<\/li><\/ol>

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