{"id":39604,"date":"2024-06-19T12:33:10","date_gmt":"2024-06-19T19:33:10","guid":{"rendered":"https:\/\/womensvoice.com\/en-us\/?p=39604"},"modified":"2024-07-02T13:25:04","modified_gmt":"2024-07-02T20:25:04","slug":"maximize-berberines-bioavailability","status":"publish","type":"post","link":"https:\/\/womensvoice.com\/en-us\/articles\/health\/maximize-berberines-bioavailability\/","title":{"rendered":"Maximize Berberine&#8217;s Bioavailability"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; fullwidth=&#8221;on&#8221; _builder_version=&#8221;4.16&#8243; collapsed=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_fullwidth_image src=&#8221;https:\/\/womensvoice.com\/en-us\/wp-content\/uploads\/sites\/3\/2024\/06\/berberine_banner.png&#8221; alt=&#8221;Title: The Soil Crisis.<br \/>\nImage of a bare foot on brown soil&#8221; title_text=&#8221;berberine_banner&#8221; admin_label=&#8221;Fullwidth Image&#8221; _builder_version=&#8221;4.25.2&#8243; vertical_offset_tablet=&#8221;0&#8243; horizontal_offset_tablet=&#8221;0&#8243; z_index_tablet=&#8221;500&#8243; box_shadow_horizontal_tablet=&#8221;0px&#8221; box_shadow_vertical_tablet=&#8221;0px&#8221; box_shadow_blur_tablet=&#8221;40px&#8221; box_shadow_spread_tablet=&#8221;0px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_fullwidth_image][et_pb_fullwidth_code raw_content_tablet=&#8221;<\/p>\n<p>Parents face ongoing challenges in raising healthy, well-nourished children in a world where sugary temptations lurk around every corner.<\/p>\n<p>&#8221; raw_content_phone=&#8221;&#8221; raw_content_last_edited=&#8221;on|desktop&#8221; admin_label=&#8221;Text &#8211; Fullwidth Leader Text&#8221; module_id=&#8221;fullwidth-leader-text&#8221; _builder_version=&#8221;4.25.2&#8243; vertical_offset_tablet=&#8221;0&#8243; horizontal_offset_tablet=&#8221;0&#8243; z_index_tablet=&#8221;500&#8243; box_shadow_horizontal_tablet=&#8221;0px&#8221; box_shadow_vertical_tablet=&#8221;0px&#8221; box_shadow_blur_tablet=&#8221;40px&#8221; box_shadow_spread_tablet=&#8221;0px&#8221; global_colors_info=&#8221;{}&#8221;]<pee><!-- [et_pb_line_break_holder] -->In natural health remedies, berberine stands out as a potent plant compound that offers multiple health benefits.<!-- [et_pb_line_break_holder] --><\/pee><!-- [et_pb_line_break_holder] --><!-- [et_pb_line_break_holder] --><!-- [et_pb_line_break_holder] -->[\/et_pb_fullwidth_code][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; collapsed=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;Text &#8211; Body Content&#8221; _builder_version=&#8221;4.25.2&#8243; header_font=&#8221;|700|||||||&#8221; header_text_color=&#8221;#509aa6&#8243; header_font_size=&#8221;40px&#8221; header_line_height=&#8221;40px&#8221; vertical_offset_tablet=&#8221;0&#8243; horizontal_offset_tablet=&#8221;0&#8243; hover_enabled=&#8221;0&#8243; header_font_size_tablet=&#8221;&#8221; header_font_size_phone=&#8221;30px&#8221; header_font_size_last_edited=&#8221;on|phone&#8221; header_letter_spacing_last_edited=&#8221;off|phone&#8221; header_line_height_tablet=&#8221;&#8221; header_line_height_phone=&#8221;30px&#8221; header_line_height_last_edited=&#8221;on|phone&#8221; z_index_tablet=&#8221;500&#8243; text_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; text_text_shadow_vertical_length_tablet=&#8221;0px&#8221; text_text_shadow_blur_strength_tablet=&#8221;1px&#8221; link_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; link_text_shadow_vertical_length_tablet=&#8221;0px&#8221; link_text_shadow_blur_strength_tablet=&#8221;1px&#8221; ul_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; ul_text_shadow_vertical_length_tablet=&#8221;0px&#8221; ul_text_shadow_blur_strength_tablet=&#8221;1px&#8221; ol_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; ol_text_shadow_vertical_length_tablet=&#8221;0px&#8221; ol_text_shadow_blur_strength_tablet=&#8221;1px&#8221; quote_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; quote_text_shadow_vertical_length_tablet=&#8221;0px&#8221; quote_text_shadow_blur_strength_tablet=&#8221;1px&#8221; header_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; header_text_shadow_vertical_length_tablet=&#8221;0px&#8221; header_text_shadow_blur_strength_tablet=&#8221;1px&#8221; header_2_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; header_2_text_shadow_vertical_length_tablet=&#8221;0px&#8221; header_2_text_shadow_blur_strength_tablet=&#8221;1px&#8221; header_3_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; header_3_text_shadow_vertical_length_tablet=&#8221;0px&#8221; header_3_text_shadow_blur_strength_tablet=&#8221;1px&#8221; header_4_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; header_4_text_shadow_vertical_length_tablet=&#8221;0px&#8221; header_4_text_shadow_blur_strength_tablet=&#8221;1px&#8221; header_5_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; header_5_text_shadow_vertical_length_tablet=&#8221;0px&#8221; header_5_text_shadow_blur_strength_tablet=&#8221;1px&#8221; header_6_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; header_6_text_shadow_vertical_length_tablet=&#8221;0px&#8221; header_6_text_shadow_blur_strength_tablet=&#8221;1px&#8221; box_shadow_horizontal_tablet=&#8221;0px&#8221; box_shadow_vertical_tablet=&#8221;0px&#8221; box_shadow_blur_tablet=&#8221;40px&#8221; box_shadow_spread_tablet=&#8221;0px&#8221; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p>In natural health remedies, berberine stands out as a potent plant compound that offers multiple health benefits. However, studies report berberine\u2019s <strong>low bioavailability<\/strong> and poor absorption in the body (at less than 5%) after oral intake.<\/p>\n<h5><strong><span class=\"Apple-converted-space\">WHAT IS <em>BIOAVAILABILITY<\/em>, AND <em>WHY<\/em> DOES IT MATTER?<\/span><\/strong><\/h5>\n<p>Have you ever taken a supplement and wondered if it worked for you? The answer lies in a principle known as \u201cbioavailability.\u201d Bioavailability determines how well your body absorbs a compound, like a drug or nutrient.<\/p>\n<p>\u2022 <strong>High bioavailability<\/strong> means more substance will be absorbed into the bloodstream, enhancing its effectiveness to maximize the benefits received.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p>\u2022<strong> Low bioavailability<\/strong> means that higher amounts are necessary for health benefits, resulting in more significant expenses and a higher risk of side effects.<span class=\"Apple-converted-space\">\u00a0\u00a0 <\/span><span class=\"Apple-converted-space\"><br \/><\/span><\/p>\n<p>Just like so many other natural\/herbal compounds, berberine faces absorption challenges in the body because of its poor water solubility and rapid metabolism by the gut and liver. Generally, a compound absorbs best when it has both water and fat solubility so it can pass through the gastrointestinal environment and penetrate the cell membranes to ultimately reach the bloodstream. Furthermore, smaller compounds are generally better absorbed by our cells than larger ones.<span class=\"Apple-converted-space\">\u00a0 \u00a0<\/span><\/p>\n<h5><strong>BERBERINE&#8217;S BIOAVAILABILITY<\/strong><\/h5>\n<p>Scientists are exploring different formulations (so-called \u201cdelivery systems\u201d) to enhance berberine\u2019s absorption, and increase its bioavailability within the body. To date, only a few human clinical studies have been conducted on advanced delivery systems of berberine.<\/p>\n<p>As a group of leading scientists in a new clinical study, my colleagues and I found that <strong>LipoMicel<\/strong><sup>\u00ae<\/sup><b>,<\/b> a new delivery system of berberine, has up to six times better absorption in human participants than standard berberine. In a second study, LipoMicel achieved blood glucose reductions of 12% in participants in as little as two days, with only two doses of 500 mg\/day. For comparison, in most clinical studies, standard berberine treatment, administered at a higher dose of 900\u20132000 mg\/day, would take at least <i>two weeks<\/i> to reduce blood glucose in type 2 diabetes patients.<\/p>\n<h5><strong>HOW DOES LIPOMICEL WORK?<\/strong><\/h5>\n<p>LipoMicel disperses berberine into microparticles, mixing it with both water-soluble and fat-soluble ingredients to create a natural emulsion (i.e., an oil-in-water mixture, like a vinaigrette!). These tiny particles, called <strong>micelles,<\/strong> have a unique structure with a core like oils (lipophilic) and an outer part like water (hydrophilic). <span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p>By encapsulating and solubilizing berberine in LipoMicel, berberine can safely travel through the digestive system \u2013 protected from degradation by enzymes \u2013 to reach the bloodstream and, ultimately, the tissue\u2019s target(s).<span class=\"Apple-converted-space\">\u00a0 \u00a0<\/span><\/p>\n<h5><strong><span class=\"Apple-converted-space\">BENEFITS OF A HIGH BIOAVAILABLE FORMULATION<\/span><\/strong><\/h5>\n<p>Formulations with higher bioavailability can provide <strong>faster and greater<\/strong> health benefits than standard formulations. More importantly, because of the higher absorption, lower doses of berberine can be used, which reduces the risk of common gastrointestinal side effects such as constipation or an upset stomach.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<h5><strong>RISKS, SIDE EFFECTS, AND INTERACTIONS WITH BERBERINE LIPOMICEL<\/strong><\/h5>\n<p>In a 30-day study, LipoMicel proved safe. No significant changes in blood markers, such as liver and kidney functions, were observed, and study participants reported no side effects.<\/p>\n<p>As berberine can interact with many drugs, which can potentially cause serious side effects, it should not be taken at the same time as other medications. It should also not be used during pregnancy as there\u2019s not enough clinical evidence on berberine\u2019s use in pregnant women.<\/p>\n<h5><strong>THE BEST TIME TO TAKE BERBERINE<\/strong><\/h5>\n<p>It\u2019s best to take berberine together with a meal, or shortly after, to take advantage of the blood glucose and lipid spikes associated with eating. For example, take it after a heavy\/sugary late-night dinner to prevent a spike in blood sugar levels, which can interfere with the body\u2019s natural sleep-wake cycle.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<h5><strong><span class=\"Apple-converted-space\">ARE ALL BERBERINE SUPPLEMENTS CREATED EQUAL?<\/span><span class=\"Apple-converted-space\">\u00a0 \u00a0<\/span><\/strong><\/h5>\n<p>Unlike other formulations, LipoMicel technology has been clinically studied in numerous human trials, showing better absorption and clinical efficacy, with results published in peer-reviewed journals. <span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p>If you want the maximum health benefits, choose a product tested in human clinical trials like LipoMicel, ensuring efficacy and safety. Remember, always choose supplements that prioritize quality \u2013 look for the ISURA<sup>\u00ae<\/sup> seal, a third-party testing certification.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n<span class=\"et_bloom_bottom_trigger\"><\/span>","protected":false},"excerpt":{"rendered":"<p>In natural health remedies, berberine stands out as a potent plant compound that offers multiple health benefits. However, studies report berberine\u2019s low bioavailability and poor absorption in the body (at less than 5%) after oral intake. WHAT IS BIOAVAILABILITY, AND WHY DOES IT MATTER? Have you ever taken a supplement and wondered if it worked [&hellip;]<\/p>\n","protected":false},"author":82,"featured_media":39613,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","apple_news_api_created_at":"","apple_news_api_id":"","apple_news_api_modified_at":"","apple_news_api_revision":"","apple_news_api_share_url":"","apple_news_cover_media_provider":"image","apple_news_coverimage":0,"apple_news_coverimage_caption":"","apple_news_cover_video_id":0,"apple_news_cover_video_url":"","apple_news_cover_embedwebvideo_url":"","apple_news_is_hidden":"","apple_news_is_paid":"","apple_news_is_preview":"","apple_news_is_sponsored":"","apple_news_maturity_rating":"","apple_news_metadata":"\"\"","apple_news_pullquote":"","apple_news_pullquote_position":"","apple_news_slug":"","apple_news_sections":[],"apple_news_suppress_video_url":false,"apple_news_use_image_component":false,"footnotes":""},"categories":[14,1],"tags":[],"class_list":["post-39604","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-expert-advice","category-health","et-has-post-format-content","et_post_format-et-post-format-standard"],"apple_news_notices":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.3 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Maximize Berberine&#039;s Bioavailability - Women&#039;s Voice (US)<\/title>\n<meta name=\"description\" content=\"Have you ever taken a supplement and wondered if it worked for you? 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