Naturally found in plants, fruits, and seeds, bioflavonoids are important phytochemicals that promote health. Since they’re such a large family of compounds, bioflavonoids are categorized into different groups based on their structure, including isoflavones, anthocyanins, and flavonols. The most well-known flavonol is quercetin.

First discovered by Nobel Prize recipient Albert Szent-Györgyi, quercetin can be found in a variety of foods such as apples, grapes, berries, onions, buckwheat, tomatoes, capers, red wine, citrus fruits, and black tea. While there’s no shortage of foods that provide benefits, additional health gains can be reached with the use of quercetin supplements to obtain therapeutic amounts of this valuable nutrient. In fact, supplemental quercetin is often sourced from the Sophora japonica tree flower bud, which has long been used in traditional Chinese medicine to address high blood pressure, hemorrhoids, headaches, and more.

Quercetin is a well-known antioxidant, helping to protect us against oxidative stress due to factors such as unhealthy lifestyles and environmental toxins. It is an even more powerful antioxidant when compared with vitamins C and E. Quercetin has been identified as a blood vessel protectant and recognized for its anti-inflammatory and antimicrobial activities. Therefore, quercetin may help support concerns related to allergies, heart disease, bone health, and immunity.

Quercetin’s efficacy is limited by its low solubility and absorption. In foods, quercetin is naturally bound to sugar molecules to form quercetin glycoside. When extracted for supplements, these sugar molecules are removed, producing quercetin aglycone, a form that is difficult to absorb. In addition, quercetin is soluble in fat, but not water. Why is this important? Not all quercetin supplements are created equal, and it’s important to look for ones that use methods to improve quercetin’s bioavailability. Making quercetin water-soluble and using other delivery systems such as liposomes and micelles can enhance its solubility and absorption, compared to standard quercetin supplements.

Enzymatically modified isoquercitrin

Enzymatically modified isoquercitrin, or EMIQ, is a water-soluble, highly bioavailable form of quercetin. This form of quercetin has a higher bioavailability than quercetin aglycone and provides greater health benefits than quercetin. EMIQ is approved as a safe food additive and antioxidant. Recent research on EMIQ has shown its antioxidant effects and ability to increase muscle mass among American football players when used in a protein powder supplement. Plus, it has been shown to improve endothelial function in individuals at risk for cardiovascular disease.

Quercetin LipoMicel

The Quercetin LipoMicel formulation provides an innovative delivery system to enhance quercetin’s absorption. LipoMicel uses a unique patent-pending technology that disperses quercetin into tiny micro-droplets. “Micelle” is the name given to these micro-droplets that are a few microns or smaller in size. This type of quercetin has been shown to lead to up to 10 times higher absorption than standard forms of quercetin.

Final comments

Quercetin is typically recommended at a dose of 500–1000 mg per day and appears to be safe and without any significant adverse effects when used as an oral supplement at this dose for three months. Quercetin appears to work synergistically with vitamin C and there is benefit in using these two nutrients together. Vitamin C’s ability to recycle oxidized quercetin, and the antioxidant and antiviral properties of both nutrients, make them an effective team for immune health.


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